Principal Scientist - PPDM ADME Biologics

Date: Nov 27, 2018

Location: South San Francisco, CA, US

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Requisition ID: BIO005375

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.

At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) function of MRL in Palo Alto/South San Francisco is seeking a dynamic and collaborative scientist for the Absorption, Distribution, Metabolism and Excretion (ADME) group.  The Principal Scientist will be a senior member of the function providing strong expertise as a key component of the multi-disciplinary drug discovery effort in South San Francisco, with a focus on supporting preclinical development of therapeutics of all modalities (antibody, nanobody, ADC (antiobody-drug conjugates), BDC (biologic-drug conjugates, oncolytic viruses, proteins..) through integrated understanding of drug disposition and pharmacology.  Therapeutic areas may include immunology and oncology, cardiovascular and metabolic disease, and ophthalmology.

The position will be a critical member of the function providing strong expertise necessary for development of:
  • Drug and combination therapeutic concepts and dose predictions for the design and conduct of preclinical efficacy and nonclinical safety studies
  • Computational biology and systems pharmacology principles in order to establish and build predictive preclinical drug combination frameworks with application in various therapeutic areas  
  • Mechanistic approaches (and in an integrated fashion) for integration of key properties such as--target expression, gene profiles, signaling and pathways, construct properties, disease considerations-- for establishing exposure-response relationships in relevant preclinical studies and assisting in projection of doses in early human clinical studies in support of IND submissions.
  • Network analysis and application of bioinformatics principles in data mining and evaluation/interpretation of complex biological systems
  • Independently managing functional deliverables, collaborating with the senior PK/PD scientists for implementation of advanced systems pharmacology and quantitative approaches in support of nonclinical development of various projects (from discovery to FIH studies).
  • Collaborates and coordinates extensively and effectively across functions and both internally and externally to achieve program deliverables as part of a team.
The successful candidate will collaborate closely with other research functions at South San Francisco and across the global Merck organization (including other PPDM groups, Protein Sciences, Chemistry, Biology, Pharmacology, Translational Medicine, Pharmaceutical Sciences) to drive new therapeutic opportunities leveraging the modalities that are most likely to succeed.


Education Minimum Requirement:

  • PhD. In Pharmaceutical Sciences, Pharmacology, Computational Biology, Biomedical Engineering, Mathematical Sciences with focus on Biostatistics, Biochemical Engineering  with strong background in quantitative sciences and systems approaches


Required Experience and Skills**:

  • 8 + years of combined industry and/or postdoctoral experience in relevant field with strong focus on application of quantitative sciences in drug and biologics development


Preferred Experience and Skills:

  • Background in principal of drug development with focus on quantitative and systems pharmacology
  • Biotechnology or pharmaceutical experience with protein therapeutics and familiarity with the fundamentals of pharmacology, physiology and basic principles of drug actions, and the drug development process
  • Experience in PK-PD modeling, simulations and application of biostatistics and PK-PD approaches
  • Experience with MATLAB, NONMEM, SAS, S-Plus/R, SAAM II, ADAPT and/or other modeling/simulation program is required
  • Strong communication, writing skills, and ability to function in a highly team-oriented environment

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at

Job: Biology-Discovery
Other Locations:
Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings: 1
Shift (if applicable): N/A
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

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