Associate Principal Scientist, Computational Biology/Data Science

Date: Jun 27, 2019

Location: Boston, MA, US

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Requisition ID: BIO005536

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

We are seeking a highly motivated and enthusiastic computational scientist to join a team dedicated to advancing Merck’s Oncology and Immuno-Oncology pipelines.  

The successful candidate will:

* Analyze, visualize and summarize NGS and other molecular data from oncology clinical trials and proprietary and public large molecular databases.

* Use oncology molecular data to identify biomarkers and molecularly defined groups of patients most likely to benefit from individual therapies, with a focus on translating biomarker-driven strategies into the clinic.

* Effectively present data analyses to inform and interact with stakeholders representing  a wide span of internal organizations, including Therapeutic Area Biology, Pharmacology, Statistics, Translational Medicine, Clinical Development, Commercial, Medical Affairs and Regulatory.


Education Minimum Requirement: 

* PhD in Engineering, Applied Mathematics, Bioinformatics, Computational Biology or related field with a significant computational and statistical component.

* 4+ years post-PhD experience applying computational methods in cancer biology in a pharma, biotech or academic setting.

Required Experience and Skills**: 

* 4+ years experience and demonstrated expertise with scientific computation environments (Matlab and/or R highly preferred).

* Hands-on analysis experience with large genetic, genomic, and clinical datasets, with proven record of impact on the drug development process.

* Experience with a matrix environment and ability to effectively collaborate with colleagues from a wide range of disciplines.

* Strong communication and presentation skills; ability to guide and influence decisions through use of data-driven hypotheses.

* Independent, flexible and collaborative mindset.

Preferred Experience and Skills:

* Hands-on experience with key NGS bioinformatics tools  (BWA, GATK etc) and with linux high performance environment (shell scripting, python). 

* Understanding of the major concepts of immuno-oncology biology and of the interaction between tumor and the immune system as represented in molecular data.

* Experience with analysis of data originating from clinical trials.

* Working knowledge of methods of statistical learning and application to biological problems.

* Experience with modern data mining techniques including ANNs.

* Record of publishing in high profile scientific journals.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of it’s manifestations.

Job: Bioinformatics
Other Locations:
Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings: 1
Shift (if applicable): N/A
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: Boston

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