Associate Principal Scientist, Crystallization Lab

Date: Jul 7, 2019

Location: Rahway, NJ, US

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Requisition ID: PRO018805

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.


Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

 

The Crystallization Lab within Process Research & Development is seeking a highly motivated and technically focused crystallization subject matter expert who is looking for an opportunity to develop crystallization/precipitation processes designed to deliver desired solid state properties, purity, and yield for development programs within our diverse pipeline. This position also involves the development of new technologies focused on improving the efficiency of laboratory crystallization development and to provide greater depth of process understanding.  The application of state-of-the art tools including PAT and process modeling will be integral to the role.


The position is intended to have a heavy hands-on, lab-based component with the incumbent carrying out independent research which involves conceiving, designing, planning, and implementing advanced studies aimed at achieving mechanistic understanding that informs rational process design. A high level of innovation, creativity, and self-initiative along with the ability to balance work across multiple projects will be expected. Work will be conducted at scales spanning the range from laboratory scale to multi-kilogram scale in order to understand and address scale-up issues and deliver material for downstream studies. 

 

Strong communication and collaboration skills are also critical to success in this role, as impact broadly across the organization is expected.  Specifically, the role involves considerable cross-functional collaboration as part of integrated drug substance/drug product teams that collectively drive decisions related to the choice of API form and physical attributes.  Mentoring of chemistry and engineering colleagues to share best practice and guide their development toward efficiently achieved successful outcomes is a central expectation of the role.

Qualifications

Education Minimum Requirement: 


BS in Chemical Engineering from an accredited college/university plus at least 12 years of relevant work experience in crystallization process development.

MS in Chemical Engineering from an accredited college/university plus at least 8 years of relevant work experience in crystallization process development.

PhD in Chemical Engineering from an accredited college/university with at least 4 years of relevant work experience post PhD graduation.

 

Required Experience and Skills**:

• Extensive (> 5 years, inclusive of time in academia) experience performing crystallization process development

• Expert-level experience with crystallization Process Analytical Tools (i.e. FTIR, FBRM, Raman, PVM)

• Experience with process modeling (e.g., population balance modeling, distillation modeling)

• Familiarity with Design of Experiments methodology

• Experience with process scale-up and/or technology transfer, moving from laboratory to pilot plant or production scale.


Preferred Experience and Skills:

• Experience with chemical engineering-related technology development

• Familiarity with drug product processing and experience collaborating across the drug substance/drug product interface

• Familiarity with concepts and application of cGMP during pharmaceutical development and production

 

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 

 

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.

  

Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

 

For more information about personal rights under Equal Employment Opportunity, visit:

 

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of it’s manifestations.


Job: Process Engineering
Other Locations:
Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings: 1
Shift (if applicable): N/A
Hazardous Materials: A variety of chemicals and solvents are associated with the position
Company Trade Name: Merck


Nearest Major Market: New York City
Nearest Secondary Market: Newark

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