Quantitative Pharmacology & Pharmacometrics

Who we are.

We translate breakthrough biomedical research into meaningful new therapies and vaccines that help improve and extend the lives of people worldwide. Through strengths in model-informed drug discovery/development, pharmacokinetics/pharmacodynamics, clinical pharmacology, biopharmaceutics and regulatory acumen we aim to advance high-quality, differentiated programs in the most streamlined path to registration in collaboration with our partners.

The department is made up of over 70 quantitative scientists with the majority distributed between West Point, PA and Rahway, NJ and smaller groups in Boston, MA and South San Francisco, CA. Co-location with our key discovery and development partners enables us to deliver on our purpose while flexible work arrangements enable our group to balance work and life.

The department has groups aligned to therapeutic areas (TAs) that create deeper understanding in TA biology, relevant clinical endpoints, patient populations and the competitive landscape. This allows us to optimally tailor our quantitative contributions to drive impact. In addition, a dedicated pharmacometrics group harbors deep modeling and simulation expertise and focuses on applying state-of-the-art quantitative approaches.

QP2 aims to deliver significant value through optimizing dosage, identifying opportunities to halt development of undifferentiated assets and streamlining the development of promising compounds and biologics, all of which contribute to life-changing therapies for patients. Our core strength has been in the areas of dose selection and characterization of pharmacokinetic (PK) and pharmacodynamic (PD) properties, while we continue to grow our strategy in areas such as informing modeling strategies for emerging modalities, patient selection strategies through disease progression and biomarker modeling, portfolio decisions through comparator modeling and continuing staged growth in integrating pharmacometrics with AI/ML workflows.

Our story by the numbers.

We embrace a dynamic workforce:

How we work.

Our purpose is only made possible through the strength of our people, focus on the portfolio, collaborative approach, investment in emerging science and the robustness of our processes. We pride ourselves on:

We invest in talent.

We are passionate about developing talent by empowering our scientists through continuous learning, growth opportunities and active coaching. We believe that bringing together individuals with varied experiences and perspectives strengthens our ability to solve problems creatively and collaborate effectively across disciplines.

Hear from our employees who innovate every day.

Building on my College of Pharmacy faculty background, my transformative tenure at Merck QP2 applied technical expertise to novel immune disease treatments. Transitioning from theory to practical therapies has shaped my career. Clinical research directly improves patient outcomes, strengthening my commitment to bridging meaningful discoveries with clinical breakthroughs.

Gurkishan Chadh

Director

My experience in the department has been incredibly positive. The team creates a supportive and energising environment where learning is encouraged and new ideas are welcomed. I’m grateful for the opportunity to grow as a scientist while contributing to innovative and meaningful work. I especially appreciate the opportunity to apply a versatile range of quantitative tools to generate insights that support programme decision-making, guide development strategies, and contribute to portfolio progress.

Zeyuan Wang

Senior Specialist

I value the intersection of science and operations in my role. Collaborating with other scientists to review and interpret clinical study data is rewarding, and I appreciate contributing to analyses across therapeutic areas that inform key program decisions.

Shruti Patel

Specialist

I am energized by the opportunity to use quantitative science to influence important development and regulatory decisions that ultimately impact patients. The ability to work across multiple therapeutic areas and throughout the drug development continuum, alongside exceptional colleagues, provides a breadth of experience and scientific impact that is difficult to find elsewhere.

Joe Raybon

Director

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